Objectives: To evaluate serum thyroglobulin and anti-thyroglobulin concentration and its relation with some features of differentiated thyroid cancer patients. Subjects and methods: A crosssectional study was implemented on 168 differentiated thyroid cancer patients. All patients had been quantified serum thyroglobulin and anti- thyroglobulin by radioimmunoassay methods. Results: The mean serum thyroglobulin and anti- thyroglobulin concentration was 20.03 µg/L and 33.75 UI/mL, respectively.