The development of point-of-care tests that are accurate, simple, rapid, low cost, and that do not require high levels of training for their interpretation is integral to improving the syndromic management algorithms for vaginal discharge that at present perform poorly. The present study aimed at evaluating the usefulness of assessing the bacterial sialidase activity as a rapid, sensitive and specific alternative compared to routine diagnostic methods for diagnosis of bacterial vaginosis (BV). The study included 50 female patients presenting with excessive and/or abnormal vaginal discharge.