The aim of this study is: To assess the anti-cancer effects of 131I-nimotuzumab on immune deficient mouse bearing human laryngeal cancer. In this study, we used EGFR-specific monoclonal antibody, nimotuzumab in combination with 131I to form 131I-nimotuzumab complex, and evaluated the antitumor activity of this complex in immunocompromised mice xenografted with the human laryngeal cancer line Hep2. This is the initial basis for the development of this complex application for laryngeal cancer treatment in the future.