A large number of the world’s population suffer from depression and anxieties at some points in their life time, the sufferers are however sceptical about the available orthodox drugs largely because of side effects, cost and availability. This present study was aimed at evaluating the antidepressant potentials of Voacanga africana to query its ethno medicinal claim. The extract of the stem-bark of the plant was screened for its phytochemical composition, and antidepressant potentials assessed using forced swimming test (FST) and tail suspension test (TST).