A 2-year prospective study was carried out on 110 children with clinical suspicion of meningitis where C-reactive protein (CRP) determination and routine cytochemical and microbiological analysis of Cerebrospinal fluid (CSF) were done for all patients. The patients were divided into four groups: Pyogenic meningitis (PM), viral meningitis (VM), tubercular meningitis (TBM) and control groups.